For those individuals taking atypical antipsychotics (such as zyprexa, abilify, etc.) to improve fluency, weight gain as well as type-2 diabetes may be a problem. According to a single randomized controlled trial, metformin (an anti-diabetic drug) may reduce weight gain, in particular, when it is combined with lifestyle interventions such as dieting and exercise.
Reference:
Wu RR, Zhao JP, Jin H, et al. Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial. JAMA. 2008;299(2):185–93. doi:10.1001/jama.2007.56-b. PMID 18182600.
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