tag:blogger.com,1999:blog-8540918619496499098.post8660968544545264875..comments2022-03-27T01:40:13.182-04:00Comments on Stutter-Mind-Body: Proposal for Beyond Pagoclone Drug TrialsUnknownnoreply@blogger.comBlogger5125tag:blogger.com,1999:blog-8540918619496499098.post-76865204990553676992010-11-11T23:17:04.146-05:002010-11-11T23:17:04.146-05:00Endo Pharmaceuticals is still analyzing the Pagocl...Endo Pharmaceuticals is still analyzing the Pagoclone IIb results and my co-investigators and I will seek publication of the data once fully analyzed. As you know, we did publish the Phase II study in the Journal of Clinical Psychopharmacology earlier this year. Also, my colleagues and I at UC Irvine will be starting a trial of asenapine for stuttering in the coming months. We have other compounds for stuttering in our pipeline development as well. Fortunately, multiple studies investigating dopamine antagonists in stuttering (e.g. haloperidol, risperidone, olanzapine) have yielded positive efficacy. Newer generation dopamine blocking agents such as asenapine and others have fewer side-effects than their predecessors and we are very excited to begin this new chapter in stuttering pharmacotherapy research. <br /><br />Again, I want to thank the author of this blog for providing this forum for discussion.Gerald Maguire, MDhttp://gerald.maguire@uci.edunoreply@blogger.comtag:blogger.com,1999:blog-8540918619496499098.post-28272450510738553992010-11-11T05:47:30.012-05:002010-11-11T05:47:30.012-05:00Now if we could get Dr. McGuire to shed some light...Now if we could get Dr. McGuire to shed some light on the outcomes of the pagoclone trials. I realize that he may be constrained by confidentiality agreements he might have made with the pharmaceutical company. But the dissemination of clinical results, even if negative, would add to the knowledge base regarding stuttering.Anonymoushttp://crossbow200@verizon.netnoreply@blogger.comtag:blogger.com,1999:blog-8540918619496499098.post-68251914941703220182010-11-11T04:19:53.490-05:002010-11-11T04:19:53.490-05:00i am happy to find it thanks for sharing it here. ...i am happy to find it thanks for sharing it here. Nice work.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8540918619496499098.post-68703174272509532242010-11-10T15:46:29.456-05:002010-11-10T15:46:29.456-05:00Thank you for writing such an informative blog.Thank you for writing such an informative blog.Gerald Maguire, MDhttp://www.kirkupcenter.uci.edunoreply@blogger.comtag:blogger.com,1999:blog-8540918619496499098.post-41573499645960813812010-11-07T07:29:29.075-05:002010-11-07T07:29:29.075-05:00i found this blog through toms blog, and have foun...i found this blog through toms blog, and have found it really useful in understanding the brain, chemical, mind body connection in relation to stuttering..<br /><br />thank you for all your good work, and keep up the excellent non egotistical writing style ;)Anonymousnoreply@blogger.com